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Canine Copper-Associated Hepatopathy is recognized with increasing frequency in dogs. While most evidence and occurrences currently points to genetics, growing studies are demonstrating it is possible that a dietary ingredient, copper (cu), plays a role due to several industry changes, which may give answers to those with an unknown etiology. The latest studies we have from veterinary experts from several different academic institutions believe that the incidence of CT with the changes in the average liver copper concentrations reported are unlikely to be due to the dogs’ excretion of copper, theorizing that diet, and not genetics, is the most critical underlying factor influencing copper accumulation in the liver of dogs.